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1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation.
Möller, Dorothee; Salama, Ismail; Kling, Ralf C; Hübner, Harald; Gmeiner, Peter.
Afiliação
  • Möller D; Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany.
  • Salama I; Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: ismail_mohamed@pharm.suez.edu.eg.
  • Kling RC; Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany.
  • Hübner H; Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany.
  • Gmeiner P; Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany. Electronic address: peter.gmeiner@fau.de.
Bioorg Med Chem ; 23(18): 6195-209, 2015 Sep 15.
Article em En | MEDLINE | ID: mdl-26299826
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Antipsicóticos / Receptores de Dopamina D2 / Receptor 5-HT2A de Serotonina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Antipsicóticos / Receptores de Dopamina D2 / Receptor 5-HT2A de Serotonina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article