Insulin resistance or hypersecretion? The ßIG picture revisited.
J Theor Biol
; 384: 131-9, 2015 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-26300065
ABSTRACT
Mathematical models of glucose, insulin and pancreatic beta-cell mass dynamics are essential to our understanding of the physiological basis of the development of type 2 diabetes. The classical view of diabetes is that the disease develops due to insulin insufficiency. An alternate viewpoint that has recently staged a revival is that diabetogenesis is a hypersecretion disorder. A prominent model of diabetes progression is the ßIG model due to Topp and coworkers. Here we study two new variants of the Topp model, which we name "Topp-IR" and "Topp-HS". Topp-IR is a model in which increasing insulin resistance is sufficient to drive a system away from health towards hyperglycemia. Topp-HS describes the hypersecretion model in mathematical terms. We thus show that the hypersecretion hypothesis is theoretically sound, and is therefore a potential route to diabetes. On the basis of insights derived from modeling, we clarify several subtleties of that argument, including postulating a central role for transient insulin peaks in driving insulin resistance.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Diabetes Mellitus Tipo 2
/
Insulina
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Modelos Biológicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article