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Exploration of the molecular architecture of the orthosteric binding site in the α4ß2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Bach, Tinna B; Jensen, Anders A; Petersen, Jette G; Sørensen, Troels E; Della Volpe, Serena; Liu, Jun; Blaazer, Antoni R; van Muijlwijk-Koezen, Jacqueline E; Balle, Thomas; Frølund, Bente.
Afiliação
  • Bach TB; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
  • Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
  • Petersen JG; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
  • Sørensen TE; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.
  • Della Volpe S; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
  • Liu J; Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.
  • Blaazer AR; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands.
  • van Muijlwijk-Koezen JE; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands.
  • Balle T; Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: thomas.balle@sydney.edu.au.
  • Frølund B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address: bfr@sund.ku.dk.
Eur J Med Chem ; 102: 425-44, 2015 Sep 18.
Article em En | MEDLINE | ID: mdl-26301559
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Azepinas / Carbamatos / Receptores Nicotínicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Azepinas / Carbamatos / Receptores Nicotínicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article