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No evidence of transmission of chronic lymphocytic leukemia through blood transfusion.
Hjalgrim, Henrik; Rostgaard, Klaus; Vasan, Senthil K; Ullum, Henrik; Erikstrup, Christian; Pedersen, Ole B V; Nielsen, Kaspar R; Titlestad, Kjell-Einar; Melbye, Mads; Nyrén, Olof; Edgren, Gustaf.
Afiliação
  • Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark;
  • Rostgaard K; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark;
  • Vasan SK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;
  • Ullum H; Department of Clinical Immunology, Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark;
  • Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark;
  • Pedersen OB; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark;
  • Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark;
  • Titlestad KE; South Danish Transfusion Service/Department of Clinical Immunology, Odense University Hospital, Odense, Denmark; and.
  • Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark;
  • Nyrén O; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;
  • Edgren G; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Hematology Centre, Karolinska University Hospital, Stockholm, Sweden.
Blood ; 126(17): 2059-61, 2015 Oct 22.
Article em En | MEDLINE | ID: mdl-26302757
Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80, 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Sangue / Linfócitos B / Leucemia Linfocítica Crônica de Células B / Reação Transfusional / Linfocitose Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Sangue / Linfócitos B / Leucemia Linfocítica Crônica de Células B / Reação Transfusional / Linfocitose Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article