Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991.
J Antibiot (Tokyo)
; 69(2): 89-96, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26306816
ABSTRACT
Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ftalimidas
/
Bacillus subtilis
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Benzofuranos
/
Meios de Cultura
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Emericella
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article