Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation.
J Infect Dis
; 213(4): 569-73, 2016 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-26310308
ABSTRACT
We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+) T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
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Infecções por HIV
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Subpopulações de Linfócitos T
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Linfócitos T CD8-Positivos
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
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Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article