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The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.
Cao, Juxiang; Dai, Xiangpeng; Wan, Lixin; Wang, Hongshen; Zhang, Jinfang; Goff, Philip S; Sviderskaya, Elena V; Xuan, Zhenyu; Xu, Zhixiang; Xu, Xiaowei; Hinds, Philip; Flaherty, Keith T; Faller, Douglas V; Goding, Colin R; Wang, Yongjun; Wei, Wenyi; Cui, Rutao.
Afiliação
  • Cao J; Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
  • Dai X; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  • Wan L; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  • Wang H; Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.
  • Zhang J; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  • Goff PS; Molecular Cell Sciences Research Centre, Canadian Cancer Society Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
  • Sviderskaya EV; Molecular Cell Sciences Research Centre, Canadian Cancer Society Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
  • Xuan Z; Department of Molecular and Cell Biology, The University of Texas at Dallas, Dallas, TX 75080, USA.
  • Xu Z; Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA.
  • Xu X; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hinds P; Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
  • Flaherty KT; Cancer Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
  • Faller DV; Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
  • Goding CR; Ludwig Institute for Cancer Research, University of Oxford, Headington, Oxford OX3 7DQ, UK.
  • Wang Y; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China. yjwang88@hotmail.com wwei@bidmc.harvard.edu rutaocui@bu.edu.
  • Wei W; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. yjwang88@hotmail.com wwei@bidmc.harvard.edu rutaocui@bu.edu.
  • Cui R; Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China. yjwang88@hotmail.com wwei@bidmc.harvard.edu ruta
Sci Signal ; 8(392): ra87, 2015 Sep 01.
Article em En | MEDLINE | ID: mdl-26329581
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proliferação de Células / Fatores de Transcrição Box Pareados / Proteólise / Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase / Melanócitos / Melanoma / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proliferação de Células / Fatores de Transcrição Box Pareados / Proteólise / Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase / Melanócitos / Melanoma / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article