Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions.
PLoS One
; 10(9): e0137221, 2015.
Article
em En
| MEDLINE
| ID: mdl-26340269
ABSTRACT
In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quimiotaxia
/
Explosão Respiratória
/
Apoptose
/
Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article