Dynamic microglial modulation of spatial learning and social behavior.
Brain Behav Immun
; 55: 6-16, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-26348580
ABSTRACT
Microglia are active players in inflammation, but also have important supporting roles in CNS maintenance and function, including modulation of neuronal activity. We previously observed an increase in the frequency of excitatory postsynaptic current in organotypic brain slices after depletion of microglia using clodronate. Here, we describe that local hippocampal depletion of microglia by clodronate alters performance in tests of spatial memory and sociability. Global depletion of microglia by high-dose oral administration of a Csf1R inhibitor transiently altered spatial memory but produced no change in sociability behavior. Microglia depletion and behavior effects were both reversible, consistent with a dynamic role for microglia in the regulation of such behaviors.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Social
/
Comportamento Animal
/
Receptor de Fator Estimulador de Colônias de Macrófagos
/
Ácido Clodrônico
/
Microglia
/
Inibidores de Proteínas Quinases
/
Aprendizagem Espacial
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article