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Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis.
Zhang, Lihan; Mori, Takahiro; Zheng, Qingfei; Awakawa, Takayoshi; Yan, Yan; Liu, Wen; Abe, Ikuro.
Afiliação
  • Zhang L; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
  • Mori T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
  • Zheng Q; State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling road 345, Shanghai 200032 (China).
  • Awakawa T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
  • Yan Y; State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling road 345, Shanghai 200032 (China).
  • Liu W; State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling road 345, Shanghai 200032 (China).
  • Abe I; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan). abei@mol.f.u-tokyo.ac.jp.
Angew Chem Int Ed Engl ; 54(45): 13462-5, 2015 Nov 02.
Article em En | MEDLINE | ID: mdl-26356484
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Acil-CoA Desidrogenases / Policetídeos / Antimicina A Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Acil-CoA Desidrogenases / Policetídeos / Antimicina A Idioma: En Ano de publicação: 2015 Tipo de documento: Article