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Impact of L-carnitine and Selenium Treatment on Testicular Apoptosis in Rats Exposed to 2.45 GHz Microwave Energy.
Saygin, M; Caliskan, S; Ozguner, M F; Gumral, N; Comlekci, S; Karahan, N.
Afiliação
  • Saygin M; Department of Physiology, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey. fizyolog@gmail.com.
  • Caliskan S; Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
  • Ozguner MF; Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
  • Gumral N; Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
  • Comlekci S; Department of Electronics and Communication, Faculty of Engineering, Suleyman Demirel University, Isparta, Turkey.
  • Karahan N; Department of Pathology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
West Indian Med J ; 64(2): 55-61, 2015 Mar.
Article em En | MEDLINE | ID: mdl-26360675
OBJECTIVE: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect. MATERIAL: Twelve-week old male Wistar albino rats were used in this study. Twenty-four rats were equally divided into four groups which were named as: sham group, EMR-only, EMR+L-carnitine (1.5 mg L-carnitine/kg/day) and EMR+Se (1.5 mg Se/kg/-every other day). RESULTS: The level of Bcl-2, Bax, caspase-3 and -8 were compared and a significant difference was found between the sham and EMR-only groups (p < 0.05), and Bcl-2, Bax, caspase-3 and -8 expressions increased in the EMR-only group. The level of Bcl-2, Bax, tumour necrosis factor-alpha (TNF-α), caspase-3 and -8 were compared and a significant difference was found between the sham and EMR+L-carnitine groups (p < 0.05) and Bcl-2, Bax, TNF-α, caspase-3 and -8 expressions increased in the EMR+L-carnitine group. The level of Bcl-2, Bax, TNF-α, caspase-3 and -8 were compared and a significant difference was found between the sham and EMR+Se groups (p < 0.05) and Bcl-2, Bax, TNF-α, caspase-3 and -8 expressions increased in the EMR+Se group. When the expression of caspase-8 was compared, a significant difference was found between the EMR-only and EMR+Se groups (p < 0.05). Caspase-8 expression decreased in EMR+Se group compared with EMR-only group. CONCLUSION: Electromagnetic radiation exposure resulted in testicular apoptosis in rats, mainly by the intrinsic pathways by down-regulated expression of caspase-8. Reduction in the activation of the intrinsic pathway of apoptosis was found higher with selenium administration compared with L-carnitine administration.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article