Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.

Henkel, Arne; Tausch, Lars; Pillong, Max; Jauch, Johann; Karas, Michael; Schneider, Gisbert; Werz, Oliver

Henkel, Arne; Tausch, Lars; Pillong, Max; Jauch, Johann; Karas, Michael; Schneider, Gisbert; Werz, Oliver.

Afiliação

Henkel A; Department for Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany. Electronic address: arne.henkel@gmail.com.
Tausch L; Institute of Pharmaceutical Chemistry, University of Frankfurt, Max-von-Laue-Str. 9, D-60439 Frankfurt, Germany. Electronic address: l.Tausch@yahoo.de.
Pillong M; Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland. Electronic address: max.pillong@novartis.com.
Jauch J; Organic Chemistry II, University of Saarland, Campus C 4.2, D-66123 Saarbrücken, Germany. Electronic address: j.jauch@mx.uni-saarland.de.
Karas M; Institute of Pharmaceutical Chemistry, University of Frankfurt, Max-von-Laue-Str. 9, D-60439 Frankfurt, Germany. Electronic address: karas@pharmchem.uni-frankfurt.de.
Schneider G; Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland. Electronic address: gisbert.schneider@pharma.ethz.ch.
Werz O; Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: oliver.werz@uni-jena.de.

Pharmacol Res ; 102: 53-60, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26361729

Assuntos

Anti-Infecciosos/metabolismo; Anti-Inflamatórios/farmacologia; Catelicidinas/metabolismo; Sistema Imunitário/efeitos dos fármacos; Triterpenos/farmacologia; Peptídeos Catiônicos Antimicrobianos; Humanos; Neutrófilos/efeitos dos fármacos

Palavras-chave

11-Keto-ß-boswellic acid (PubChem CID:9847548); 3-O-Acetyl-11-keto-ß-boswellic acid (PubChem CID: 71,463,896); 3-O-Acetyl-ß-boswellic acid (PubChem CID: 11,386,458); Boswellic acid; Cathelicidin; Cytochalasin B (PubChem CID:5311281); Frankincense; Inflammation; LL-37; LL-37 (PubChem CID: 16,198,951); Lipopolysaccharide; Lipopolysaccharide (PubChem CID: 11,970,143); N-formyl-methionyl-leucyl-phenylalanin (PubChem CID: 4364); ß-Boswellic acid (PubChem CID: 168,928)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Catelicidinas / Sistema Imunitário / Anti-Infecciosos / Anti-Inflamatórios Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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