Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.

Bikas, Athanasios; Jensen, Kirk; Patel, Aneeta; Costello, John; McDaniel, Dennis; Klubo-Gwiezdzinska, Joanna; Larin, Olexander; Hoperia, Victoria; Burman, Kenneth D; Boyle, Lisa; Wartofsky, Leonard; Vasko, Vasyl

Bikas, Athanasios; Jensen, Kirk; Patel, Aneeta; Costello, John; McDaniel, Dennis; Klubo-Gwiezdzinska, Joanna; Larin, Olexander; Hoperia, Victoria; Burman, Kenneth D; Boyle, Lisa; Wartofsky, Leonard; Vasko, Vasyl.

Afiliação

Bikas A; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Jensen K; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Patel A; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Costello J; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
McDaniel D; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Klubo-Gwiezdzinska J; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Larin O; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Hoperia V; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Burman KD; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Boyle L; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Wartofsky L; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi
Vasko V; Division of EndocrinologyDepartment of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USADepartment of PediatricsUniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4712, USABiomedi

Endocr Relat Cancer ; 22(6): 919-32, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26362676

Assuntos

Adenocarcinoma Folicular/patologia; Carcinoma Papilar/patologia; Glucose/farmacologia; Metformina/farmacologia; Neoplasias da Glândula Tireoide/patologia; Proteínas Quinases Ativadas por AMP/metabolismo; Adenocarcinoma Folicular/metabolismo; Apoptose/efeitos dos fármacos; Carcinoma Papilar/metabolismo; Proteínas de Transporte/biossíntese; Proteínas de Transporte/genética; Caspases/metabolismo; Divisão Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Meios de Cultura/química; Meios de Cultura/farmacologia; Desoxiglucose/farmacologia; Ensaios de Seleção de Medicamentos Antitumorais; Sinergismo Farmacológico; Retículo Endoplasmático/metabolismo; Chaperona BiP do Retículo Endoplasmático; Ativação Enzimática/efeitos dos fármacos; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Glicólise/efeitos dos fármacos; Glicólise/genética; Proteínas de Choque Térmico/biossíntese; Proteínas de Choque Térmico/genética; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Proteínas de Membrana/biossíntese; Proteínas de Membrana/genética; Terapia de Alvo Molecular; Proteínas de Neoplasias/biossíntese; Proteínas de Neoplasias/genética; Fosforilação/efeitos dos fármacos; Processamento de Proteína Pós-Traducional/efeitos dos fármacos; Hormônios Tireóideos/biossíntese; Hormônios Tireóideos/genética; Neoplasias da Glândula Tireoide/metabolismo; Proteínas de Ligação a Hormônio da Tireoide

Palavras-chave

cell signaling; glucose; metformin; oncosis; thyroid cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Carcinoma Papilar / Adenocarcinoma Folicular / Glucose / Metformina Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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