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Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
Rothwell, Simon; Cooper, Robert G; Lundberg, Ingrid E; Miller, Frederick W; Gregersen, Peter K; Bowes, John; Vencovsky, Jiri; Danko, Katalin; Limaye, Vidya; Selva-O'Callaghan, Albert; Hanna, Michael G; Machado, Pedro M; Pachman, Lauren M; Reed, Ann M; Rider, Lisa G; Cobb, Joanna; Platt, Hazel; Molberg, Øyvind; Benveniste, Olivier; Mathiesen, Pernille; Radstake, Timothy; Doria, Andrea; De Bleecker, Jan; De Paepe, Boel; Maurer, Britta; Ollier, William E; Padyukov, Leonid; O'Hanlon, Terrance P; Lee, Annette; Amos, Christopher I; Gieger, Christian; Meitinger, Thomas; Winkelmann, Juliane; Wedderburn, Lucy R; Chinoy, Hector; Lamb, Janine A.
Afiliação
  • Rothwell S; Centre for Genetics and Genomics, Arthritis Research UK, University of Manchester, Manchester, UK.
  • Cooper RG; Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
  • Lundberg IE; Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Miller FW; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Science, National Institutes of Health, Bethesda, Maryland, USA.
  • Gregersen PK; The Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.
  • Bowes J; Centre for Genetics and Genomics, Arthritis Research UK, University of Manchester, Manchester, UK.
  • Vencovsky J; Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Danko K; Division of Clinical Immunology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary.
  • Limaye V; Royal Adelaide Hospital and University of Adelaide, Adelaide, South Australia, Australia.
  • Selva-O'Callaghan A; Department of Internal Medicine, Vall d'Hebron Hospital, Barcelona, Spain.
  • Hanna MG; MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, UK.
  • Machado PM; MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, UK.
  • Pachman LM; Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
  • Reed AM; Department of Pediatrics, Duke University, Durham, North Carolina, USA.
  • Rider LG; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Science, National Institutes of Health, Bethesda, Maryland, USA.
  • Cobb J; Arthritis Research UK, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Platt H; Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
  • Molberg Ø; Department of Rheumatology, Oslo University Hospital, Oslo, Norway.
  • Benveniste O; Pitié-Salpêtrière Hospital, UPMC, APHP, Paris, France.
  • Mathiesen P; Paediatric Department, Naestved Hospital, Næstved, Denmark.
  • Radstake T; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Doria A; Department of Medicine, University of Padova, Padova, Italy.
  • De Bleecker J; Department of Neurology, Neuromuscular Reference Centre, Ghent University Hospital, Ghent, Belgium.
  • De Paepe B; Department of Neurology, Neuromuscular Reference Centre, Ghent University Hospital, Ghent, Belgium.
  • Maurer B; Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland.
  • Ollier WE; Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
  • Padyukov L; Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
  • O'Hanlon TP; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Science, National Institutes of Health, Bethesda, Maryland, USA.
  • Lee A; The Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.
  • Amos CI; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
  • Gieger C; Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.
  • Meitinger T; Institute of Human Genetics, Technische Universität München, Munich, Germany Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Winkelmann J; Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Wedderburn LR; Arthritis Research UK Centre for Adolescent Rheumatology, and Institute of Child Health, University College London, London, UK.
  • Chinoy H; National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.
  • Lamb JA; Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
Ann Rheum Dis ; 75(8): 1558-66, 2016 Aug.
Article em En | MEDLINE | ID: mdl-26362759
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA / Miosite Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA / Miosite Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article