Suppressors of superoxide production from mitochondrial complex III.
Nat Chem Biol
; 11(11): 834-6, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26368590
ABSTRACT
Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Pirimidinas
/
Sequestradores de Radicais Livres
/
Superóxidos
/
Complexo III da Cadeia de Transporte de Elétrons
/
Mitocôndrias
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article