Nano-Aggregates of Doxorubicin-Conjugated Methoxy Poly(ethylene glycol)-b-Carboxymethyl Dextran Copolymer.
J Nanosci Nanotechnol
; 15(8): 5566-70, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26369118
ABSTRACT
Block copolymer composed of carboxymethyl dextran (CMDex) and methoxy poly(ethylene glycol) (MPEG) (abbreviated as CMDexPEG) was synthesized and doxorubicin (DOX) was conjugated with carboxyl groups of CMDexPEG. DOX-conjugated CMDexPEG block copolymer formed nanoparticles in water with sizes less than 100 nm. DOX-conjugated nanoparticles enhanced DOX delivery to the DOX-resistant CT26 cells and showed higher anticancer activity in vitro. DOX-conjugated nanoparticles inhibited growth of CT26 solid tumor at tumor-bearing mouse model study. In near infrared (NIR)-dye study, nanoparticles were retained in the tumor tissues for a longer period.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Neoplasias Colorretais
/
Doxorrubicina
/
Dextranos
/
Nanocápsulas
/
Nanoconjugados
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article