Your browser doesn't support javascript.
loading
Imaging Cerebral Microhemorrhages in Military Service Members with Chronic Traumatic Brain Injury.
Liu, Wei; Soderlund, Karl; Senseney, Justin S; Joy, David; Yeh, Ping-Hong; Ollinger, John; Sham, Elyssa B; Liu, Tian; Wang, Yi; Oakes, Terrence R; Riedy, Gerard.
Afiliação
  • Liu W; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Soderlund K; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Senseney JS; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Joy D; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Yeh PH; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Ollinger J; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Sham EB; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Liu T; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Wang Y; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Oakes TR; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
  • Riedy G; From the National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, 4860 S Palmer Rd, Bethesda, MD 20889-5649 (W.L., K.S., J.S.S., D.J., P.H.Y., J.O., E.B.S., T.R.O., G.R.); Center for Neuroscience and Regenerative Medicine, Bethesda, Md (D.J., T.R.O., G.R.); The H
Radiology ; 278(2): 536-45, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26371749
ABSTRACT

PURPOSE:

To detect cerebral microhemorrhages in military service members with chronic traumatic brain injury by using susceptibility-weighted magnetic resonance (MR) imaging. The longitudinal evolution of microhemorrhages was monitored in a subset of patients by using quantitative susceptibility mapping. MATERIALS AND

METHODS:

The study was approved by the Walter Reed National Military Medical Center institutional review board and is compliant with HIPAA guidelines. All participants underwent two-dimensional conventional gradient-recalled-echo MR imaging and three-dimensional flow-compensated multiecho gradient-recalled-echo MR imaging (processed to generate susceptibility-weighted images and quantitative susceptibility maps), and a subset of patients underwent follow-up imaging. Microhemorrhages were identified by two radiologists independently. Comparisons of microhemorrhage number, size, and magnetic susceptibility derived from quantitative susceptibility maps between baseline and follow-up imaging examinations were performed by using the paired t test.

RESULTS:

Among the 603 patients, cerebral microhemorrhages were identified in 43 patients, with six excluded for further analysis owing to artifacts. Seventy-seven percent (451 of 585) of the microhemorrhages on susceptibility-weighted images had a more conspicuous appearance than on gradient-recalled-echo images. Thirteen of the 37 patients underwent follow-up imaging examinations. In these patients, a smaller number of microhemorrhages were identified at follow-up imaging compared with baseline on quantitative susceptibility maps (mean ± standard deviation, 9.8 microhemorrhages ± 12.8 vs 13.7 microhemorrhages ± 16.6; P = .019). Quantitative susceptibility mapping-derived quantitative measures of microhemorrhages also decreased over time -0.85 mm(3) per day ± 1.59 for total volume (P = .039) and -0.10 parts per billion per day ± 0.14 for mean magnetic susceptibility (P = .016).

CONCLUSION:

The number of microhemorrhages and quantitative susceptibility mapping-derived quantitative measures of microhemorrhages all decreased over time, suggesting that hemosiderin products undergo continued, subtle evolution in the chronic stage.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Imageamento por Ressonância Magnética / Interpretação de Imagem Assistida por Computador / Hemorragia Cerebral / Militares Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Imageamento por Ressonância Magnética / Interpretação de Imagem Assistida por Computador / Hemorragia Cerebral / Militares Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article