When is 'Urgent' Really Urgent and Does it Matter? Misclassification of Procedural Status and Implications for Risk Assessment in Cardiac Surgery.
Heart Lung Circ
; 25(2): 196-203, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26375500
ABSTRACT
BACKGROUND:
Many patients classified as "urgent" in Australia New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) registry contradict the prescribed definition (surgery within 72hours of angiogram or unplanned admission). The aim was to examine the impacts of this misclassification on the prediction of 30-day mortality following cardiac surgery.METHODS:
The 'reported clinical status' was compared with a 'corrected clinical status' following reclassification based on the standard definition calculated from raw data. Observed-to-predicted risk ratios (OPRs) of 30-day mortality were calculated for the model using reported status and corrected status and compared. A Bland-Altman plot was generated to examine the level of agreement between the two OPRs.RESULTS:
Of 18496 cases reported as urgent, 49.9% were operated after 72hours, leading to misclassification of 14.6% in the registry. Misclassified patients had significantly higher mortality (3.5%) than true urgent patients (2.9%). Underweight (OR1.6,CI1.2-2.1), dialysis (OR1.4,CI1.1-1.7), endocarditis (OR2.1,CI1.7-2.5), shock (OR1.6,CI1.3-2.0) and poor ejection fraction (OR1.2,CI1.1-1.4) were significant predictors of misclassification. Bland- Altman plot demonstrates significant disagreement between two risk estimates (P<0.001). Misclassification results in overestimation of risk by 9.1%. Observed-to-predicted risk increased with corrected definition (0.8975 vs 0.9875), suggesting poorer calibration with reported status.CONCLUSIONS:
In the ANZSCTS database, misclassification prevalence is 14.6%. Misclassification compromises the discrimination capacity and calibration of the model and results in overestimation of mortality risk.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema de Registros
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Mortalidade
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Procedimentos Cirúrgicos Cardíacos
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Modelos Cardiovasculares
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article