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Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding.
Marzinzik, Andreas L; Amstutz, René; Bold, Guido; Bourgier, Emmanuelle; Cotesta, Simona; Glickman, J Fraser; Götte, Marjo; Henry, Christelle; Lehmann, Sylvie; Hartwieg, J Constanze D; Ofner, Silvio; Pellé, Xavier; Roddy, Thomas P; Rondeau, Jean-Michel; Stauffer, Frédéric; Stout, Steven J; Widmer, Armin; Zimmermann, Johann; Zoller, Thomas; Jahnke, Wolfgang.
Afiliação
  • Marzinzik AL; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland. wolfgang.jahnke@novartis.com.
  • Amstutz R; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Bold G; Conim AG, Oberwiler Kirchweg 4c, 6300, Zug, Switzerland.
  • Bourgier E; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Cotesta S; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Glickman JF; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Götte M; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Henry C; High Throughput and Spectroscopy Resource Center, Rockefeller University, New York, NY, 10065, USA.
  • Lehmann S; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Hartwieg JC; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Ofner S; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Pellé X; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Roddy TP; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Rondeau JM; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Stauffer F; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Stout SJ; Agios, Cambridge, MA, 02139-4169, USA.
  • Widmer A; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Zimmermann J; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Zoller T; Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.
  • Jahnke W; Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ, 07065, USA.
ChemMedChem ; 10(11): 1884-91, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26381451
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Ácido Salicílico / Inibidores Enzimáticos / Geraniltranstransferase / Descoberta de Drogas Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Ácido Salicílico / Inibidores Enzimáticos / Geraniltranstransferase / Descoberta de Drogas Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article