Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma.

Dang, Zheng; Shangguan, Jianying; Zhang, Chao; Hu, Peng; Ren, Yanshun; Lv, Zhicheng; Xiang, Hongjun; Wang, Xianghui

Dang, Zheng; Shangguan, Jianying; Zhang, Chao; Hu, Peng; Ren, Yanshun; Lv, Zhicheng; Xiang, Hongjun; Wang, Xianghui.

Afiliação

Dang Z; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China.
Shangguan J; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China.
Zhang C; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China.
Hu P; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China.
Ren Y; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China.
Lv Z; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China.
Xiang H; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China. Doctor_hjxiang@163.com.
Wang X; The Department of Hepatobiliary Surgery, Lanzhou General Hospital of People's Liberation Army, Lanzhou, Gansu, 730050, People's Republic of China. Doctor_xhwang@163.com.

Tumour Biol ; 37(2): 2527-35, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26386721

Assuntos

Caderinas/genética; Carcinoma Hepatocelular/genética; Movimento Celular/genética; Receptores ErbB/genética; Neoplasias Hepáticas/genética; Sistema de Sinalização das MAP Quinases/genética; Metástase Neoplásica/genética; Animais; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica/genética; Humanos; Neoplasias Hepáticas/patologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Metástase Neoplásica/patologia; Prognóstico; Transdução de Sinais/genética

Palavras-chave

ERK; Hepatocellular carcinoma; Metastasis; Prognosis; Protocadherin-17 (PCDH-17)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caderinas / Movimento Celular / Carcinoma Hepatocelular / Sistema de Sinalização das MAP Quinases / Receptores ErbB / Neoplasias Hepáticas / Metástase Neoplásica Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google