Highly Regioselective Radical Amination of Allenes: Direct Synthesis of Allenamides and Tetrasubstituted Alkenes.

Zhang, Ge; Xiong, Tao; Wang, Zining; Xu, Guoxing; Wang, Xuedan; Zhang, Qian

Zhang, Ge; Xiong, Tao; Wang, Zining; Xu, Guoxing; Wang, Xuedan; Zhang, Qian.

Afiliação

Zhang G; Department of Chemistry, Northeast Normal University, Changchun, 130024 (China).
Xiong T; Department of Chemistry, Northeast Normal University, Changchun, 130024 (China).
Wang Z; Department of Chemistry, Northeast Normal University, Changchun, 130024 (China).
Xu G; Department of Chemistry, Northeast Normal University, Changchun, 130024 (China).
Wang X; Department of Chemistry, Northeast Normal University, Changchun, 130024 (China).
Zhang Q; Department of Chemistry, Northeast Normal University, Changchun, 130024 (China). Zhangq651@nenu.edu.cn.

Angew Chem Int Ed Engl ; 54(43): 12649-53, 2015 Oct 19.

Article em En | MEDLINE | ID: mdl-26387513

RESUMO

The first controllable, regioselective radical amination of allenes with N-fluoroarylsulfonimide is described to proceed under very mild reaction conditions. With this methodology, a general and straightforward route for the synthesis of both allenamides and fluorinated tetrasubstituted alkenes was realized from a wide range of terminal and internal allenes.

Assuntos

Alcadienos/química; Alcenos/química; Amidas/química; Alcadienos/síntese química; Alcenos/síntese química; Amidas/síntese química; Aminação; Catálise; Cobre/química; Halogenação; Acoplamento Oxidativo; Estereoisomerismo

Palavras-chave

allenes; copper; fluorine; radicals; transition metals

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcadienos / Alcenos / Amidas Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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