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The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles.
Zhao, Xiaohu; Liu, Xiaohua; Xiong, Qian; Mei, Hongjiang; Ma, Baiwei; Lin, Lili; Feng, Xiaoming.
Afiliação
  • Zhao X; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
  • Liu X; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
  • Xiong Q; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
  • Mei H; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
  • Ma B; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
  • Lin L; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
  • Feng X; Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
Chem Commun (Camb) ; 51(89): 16076-9, 2015 Nov 18.
Article em En | MEDLINE | ID: mdl-26389723
ABSTRACT
A highly enantioselective dearomative cascade reaction between 2-isocyanoethylindoles and 3-alkenyl-oxindoles was realized using a chiral N,N'-dioxide-Mg(II) complex catalyst. This reaction provides a straightforward access to polycyclic 3-spirooxindoles bearing cyclopenta[b]indole units with four contiguous stereocenters in excellent yields and moderate to good stereoselectivities via a Michael/Friedel-Crafts/Mannich cascade.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Policíclicos / Compostos de Espiro / Alcaloides / Indóis Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Policíclicos / Compostos de Espiro / Alcaloides / Indóis Idioma: En Ano de publicação: 2015 Tipo de documento: Article