Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.

Wickramasinghe, Vihandha O; Gonzàlez-Porta, Mar; Perera, David; Bartolozzi, Arthur R; Sibley, Christopher R; Hallegger, Martina; Ule, Jernej; Marioni, John C; Venkitaraman, Ashok R

Wickramasinghe, Vihandha O; Gonzàlez-Porta, Mar; Perera, David; Bartolozzi, Arthur R; Sibley, Christopher R; Hallegger, Martina; Ule, Jernej; Marioni, John C; Venkitaraman, Ashok R.

Afiliação

Wickramasinghe VO; The Medical Research Council Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge, CB2 0XZ, UK.
Gonzàlez-Porta M; European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Perera D; The Medical Research Council Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge, CB2 0XZ, UK.
Bartolozzi AR; The Medical Research Council Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge, CB2 0XZ, UK.
Sibley CR; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Hallegger M; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Ule J; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Marioni JC; European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Venkitaraman AR; The Medical Research Council Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge, CB2 0XZ, UK. arv22@mrc-cu.cam.ac.uk.

Genome Biol ; 16: 201, 2015 Sep 21.

Article em En | MEDLINE | ID: mdl-26392272

Assuntos

Processamento Alternativo/genética; Proteínas de Ligação a RNA/genética; Retinose Pigmentar/genética; Transcriptoma/genética; Éxons/genética; Genoma; Humanos; Íntrons/genética; Mutação; Sítios de Splice de RNA; RNA Mensageiro/genética; Retinose Pigmentar/patologia; Ribonucleoproteínas/genética; Spliceossomos/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retinose Pigmentar / Proteínas de Ligação a RNA / Processamento Alternativo / Transcriptoma Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google