Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia.
Antimicrob Agents Chemother
; 59(12): 7837-41, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26392488
ABSTRACT
A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMérieux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, >1.0 µg/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P < 0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cefalosporinas
/
Farmacorresistência Bacteriana Múltipla
/
Staphylococcus aureus Resistente à Meticilina
/
Antibacterianos
Limite:
Humans
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article