Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance.

Jensen, Victor L; Li, Chunmei; Bowie, Rachel V; Clarke, Lara; Mohan, Swetha; Blacque, Oliver E; Leroux, Michel R

Jensen, Victor L; Li, Chunmei; Bowie, Rachel V; Clarke, Lara; Mohan, Swetha; Blacque, Oliver E; Leroux, Michel R.

Afiliação

Jensen VL; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC, Canada.
Li C; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC, Canada.
Bowie RV; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Clarke L; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Mohan S; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC, Canada.
Blacque OE; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Leroux MR; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC, Canada leroux@sfu.ca.

EMBO J ; 34(20): 2537-56, 2015 Oct 14.

Article em En | MEDLINE | ID: mdl-26392567

Assuntos

Proteínas de Caenorhabditis elegans/metabolismo; Caenorhabditis elegans/metabolismo; Estruturas da Membrana Celular/metabolismo; Cílios/metabolismo; Modelos Biológicos; Transdução de Sinais/fisiologia; Animais; Animais Geneticamente Modificados; Proteínas de Caenorhabditis elegans/genética; Estruturas da Membrana Celular/ultraestrutura; Cílios/ultraestrutura; Fluorescência; Técnicas de Inativação de Genes; Genótipo; Microscopia Eletrônica de Transmissão; Mutação de Sentido Incorreto/genética; Reação em Cadeia da Polimerase

Palavras-chave

MKS5; PIP2; cilia; ciliary gate; transition zone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Cílios / Caenorhabditis elegans / Estruturas da Membrana Celular / Proteínas de Caenorhabditis elegans / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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