Fitting the Pieces of the ß-Barrel Assembly Machinery Complex.
Biochemistry
; 54(41): 6303-11, 2015 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-26394220
ABSTRACT
ß-Barrel membrane proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria; however, exactly how they are folded and inserted remains unknown. Over the past decade, both functional and structural studies have greatly contributed to addressing this elusive mechanism. It is known that a conserved core machinery is required for each organelle, though the overall composition varies significantly. The vast majority of studies that aimed to understand the biogenesis of ß-barrel membrane proteins has been conducted in Gram-negative bacteria. Here, it is the task of a multicomponent complex known as the ß-barrel assembly machinery (BAM) complex to fold and insert new ß-barrel membrane proteins into the outer membrane. In this review, we will discuss recent discoveries with the goal of utilizing all reported structural and functional studies to piece together a current structural model for the fully assembled BAM complex.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas da Membrana Bacteriana Externa
/
Bactérias Gram-Negativas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article