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Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking.
Pfefferbaum, Adolf; Rohlfing, Torsten; Pohl, Kilian M; Lane, Barton; Chu, Weiwei; Kwon, Dongjin; Nolan Nichols, B; Brown, Sandra A; Tapert, Susan F; Cummins, Kevin; Thompson, Wesley K; Brumback, Ty; Meloy, M J; Jernigan, Terry L; Dale, Anders; Colrain, Ian M; Baker, Fiona C; Prouty, Devin; De Bellis, Michael D; Voyvodic, James T; Clark, Duncan B; Luna, Beatriz; Chung, Tammy; Nagel, Bonnie J; Sullivan, Edith V.
Afiliação
  • Pfefferbaum A; Center for Health Sciences, SRI International, Menlo Park, CA, USA Department of Psychiatry and Behavioral Sciences.
  • Rohlfing T; Center for Health Sciences, SRI International, Menlo Park, CA, USA Current address: Google, Inc.
  • Pohl KM; Center for Health Sciences, SRI International, Menlo Park, CA, USA Department of Psychiatry and Behavioral Sciences.
  • Lane B; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Chu W; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • Kwon D; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • Nolan Nichols B; Center for Health Sciences, SRI International, Menlo Park, CA, USA Department of Psychiatry and Behavioral Sciences.
  • Brown SA; Department of Psychiatry.
  • Tapert SF; Department of Psychiatry Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.
  • Cummins K; Department of Psychiatry.
  • Thompson WK; Department of Psychiatry.
  • Brumback T; Department of Psychiatry.
  • Meloy MJ; Department of Psychiatry.
  • Jernigan TL; Center for Human Development.
  • Dale A; Center for Human Development Departments of Neurosciences and Radiology, University of California, San Diego, La Jolla, CA, USA.
  • Colrain IM; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • Baker FC; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • Prouty D; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • De Bellis MD; Department of Psychiatry and Behavioral Sciences.
  • Voyvodic JT; Department of Radiology, Duke University School of Medicine, Durham, NC, USA.
  • Clark DB; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Luna B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Chung T; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Nagel BJ; Department of Psychiatry Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland, OR, USA.
  • Sullivan EV; Department of Psychiatry and Behavioral Sciences.
Cereb Cortex ; 26(10): 4101-21, 2016 10.
Article em En | MEDLINE | ID: mdl-26408800
Brain structural development continues throughout adolescence, when experimentation with alcohol is often initiated. To parse contributions from biological and environmental factors on neurodevelopment, this study used baseline National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) magnetic resonance imaging (MRI) data, acquired in 674 adolescents meeting no/low alcohol or drug use criteria and 134 adolescents exceeding criteria. Spatial integrity of images across the 5 recruitment sites was assured by morphological scaling using Alzheimer's disease neuroimaging initiative phantom-derived volume scalar metrics. Clinical MRI readings identified structural anomalies in 11.4%. Cortical volume and thickness were smaller and white matter volumes were larger in older than in younger adolescents. Effects of sex (male > female) and ethnicity (majority > minority) were significant for volume and surface but minimal for cortical thickness. Adjusting volume and area for supratentorial volume attenuated or removed sex and ethnicity effects. That cortical thickness showed age-related decline and was unrelated to supratentorial volume is consistent with the radial unit hypothesis, suggesting a universal neural development characteristic robust to sex and ethnicity. Comparison of NCANDA with PING data revealed similar but flatter, age-related declines in cortical volumes and thickness. Smaller, thinner frontal, and temporal cortices in the exceeds-criteria than no/low-drinking group suggested untoward effects of excessive alcohol consumption on brain structural development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Etnicidade / Córtex Cerebral / Puberdade / Caracteres Sexuais / Substância Branca Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Etnicidade / Córtex Cerebral / Puberdade / Caracteres Sexuais / Substância Branca Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article