An increase in IL-1ß concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation.
J Assist Reprod Genet
; 32(11): 1623-7, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26409476
ABSTRACT
PURPOSE:
This study aimed to evaluate interleukin (IL)-1ß concentrations in maternal serum and in embryo-cultured conditioned media and to correlate these findings with success of implantation.METHODS:
A total of 70 infertile women who underwent in vitro fertilization treatment were studied. IL-1ß concentrations were quantified in maternal serum and in embryo culture-conditioned media on days 1 and 3. The findings were compared between those who achieved pregnancy and those who did not.RESULTS:
No significant differences were found in IL-1ß serum concentrations between the groups. IL-1ß was not detected in day 1 culture-conditioned medium. On day 3, IL-1ß was quantified in 27 patients, and IL-1ß concentrations were significantly higher in women who achieved pregnancy than in those who did not (p < 0.001).CONCLUSIONS:
High IL-1ß concentrations in day 3 culture-conditioned medium in patients who achieve pregnancy after in vitro fertilization treatment indicate a possible role of embryonic IL-1ß in the implantation process.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Fertilização in vitro
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Meios de Cultivo Condicionados
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Interleucina-1beta
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article