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CD33 modulates TREM2: convergence of Alzheimer loci.
Chan, Gail; White, Charles C; Winn, Phoebe A; Cimpean, Maria; Replogle, Joseph M; Glick, Laura R; Cuerdon, Nicole E; Ryan, Katie J; Johnson, Keith A; Schneider, Julie A; Bennett, David A; Chibnik, Lori B; Sperling, Reisa A; Bradshaw, Elizabeth M; De Jager, Philip L.
Afiliação
  • Chan G; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • White CC; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Winn PA; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Cimpean M; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Replogle JM; Harvard Medical School, Boston, Massachusetts, USA.
  • Glick LR; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Cuerdon NE; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Ryan KJ; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Johnson KA; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Schneider JA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Bennett DA; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Chibnik LB; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Sperling RA; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Bradshaw EM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • De Jager PL; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nat Neurosci ; 18(11): 1556-8, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26414614
We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Predisposição Genética para Doença / Doença de Alzheimer / Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico / Mutação Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Predisposição Genética para Doença / Doença de Alzheimer / Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico / Mutação Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article