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Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.
Pulcini, Serena; Staines, Henry M; Lee, Andrew H; Shafik, Sarah H; Bouyer, Guillaume; Moore, Catherine M; Daley, Daniel A; Hoke, Matthew J; Altenhofen, Lindsey M; Painter, Heather J; Mu, Jianbing; Ferguson, David J P; Llinás, Manuel; Martin, Rowena E; Fidock, David A; Cooper, Roland A; Krishna, Sanjeev.
Afiliação
  • Pulcini S; Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
  • Staines HM; Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
  • Lee AH; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
  • Shafik SH; Research School of Biology, Australian National University, Canberra, ACT 2601, Australia.
  • Bouyer G; Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
  • Moore CM; Sorbonne Universités, UPMC Univ. Paris 06, UMR 8227, Integrative Biology of Marine Models, Comparative Physiology of Erythrocytes, Station Biologique de Roscoff, Roscoff, France.
  • Daley DA; CNRS, UMR 8227, Integrative Biology of Marine Models, Comparative Physiology of Erythrocytes, Station Biologique de Roscoff, Roscoff, France.
  • Hoke MJ; Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
  • Altenhofen LM; Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
  • Painter HJ; Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
  • Mu J; Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, State College, Pennsylvania 16802, USA.
  • Ferguson DJ; Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, State College, Pennsylvania 16802, USA.
  • Llinás M; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville MD 20852, USA.
  • Martin RE; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • Fidock DA; Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, State College, Pennsylvania 16802, USA.
  • Cooper RA; Research School of Biology, Australian National University, Canberra, ACT 2601, Australia.
  • Krishna S; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Sci Rep ; 5: 14552, 2015 Sep 30.
Article em En | MEDLINE | ID: mdl-26420308
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Plasmodium falciparum / Vacúolos / Resistência a Medicamentos / Proteínas de Protozoários / Cloroquina / Mutação Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Plasmodium falciparum / Vacúolos / Resistência a Medicamentos / Proteínas de Protozoários / Cloroquina / Mutação Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article