Direct Catalytic Asymmetric Mannich-Type Reaction of α-N3 Amide.
Chemistry
; 21(49): 17574-7, 2015 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-26439589
ABSTRACT
An α-N3 7-azaindoline amide serves as a latent enolate to directly engage in an asymmetric Mannich-type reaction with N-thiophosphinoyl imines by the action of a cooperative catalyst. The thus-obtained highly enantioenriched anti-adduct was transformed into ß-amino-α-azido acid in high yield by simple acidic treatment.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article