[Prostatic inflammation-induced chronic pelvic pain: Roles of substance P and c-fos in the spinal cord].
Zhonghua Nan Ke Xue
; 21(8): 681-6, 2015 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-26442292
ABSTRACT
OBJECTIVE:
To explore the possible pain mechanism of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).METHODS:
The models of CP/CPPS were established in male Wistar rats by the autoimmune method. The paw withdrawal threshold (PWT) was detected using Von Frey filament. The expressions of the substance P and c-fos in the prostate and spinal L5-S2 segments were determined by immunohistochemistry followed by analysis of their correlation with CP/CPPS.RESULTS:
Compared with the control rats, the CP/CPPS models showed significantly decreased PWT (P < 0.05), remarkable prostatic inflammation, enlarged scope of lesions, and obvious interstitial lymphocytic infiltration (P < 0.05). Both the expressions of substance P and c-fos were markedly elevated in the prostate and spinal dorsal horn (L5-S2) of the rat models (P < 0.05), but the expression of substance P in the prostate exhibited no correlation with that in the spinal cord (r = 0.099, P = 0.338), nor did that of c-fos (r = 0.027, P = 0.454).CONCLUSION:
The upregulated expressions of substance P and c-fos in the spinal cord L5-S2 sections may be associated with the pain mechanism of CP/CPPS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Prostatite
/
Medula Espinal
/
Substância P
/
Proteínas Proto-Oncogênicas c-fos
/
Dor Pélvica
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article