Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.
PLoS One
; 10(10): e0139206, 2015.
Article
em En
| MEDLINE
| ID: mdl-26444559
ABSTRACT
OBJECTIVE:
Evidence suggests that substance P (SP) is involved in chronic joint inflammation, such as the pathogenesis of rheumatoid arthritis and osteoarthritis. The goal of the research was to evaluate the correlation between chronic pain and changes in the SP level in patients with chronic inflammation of the connective tissue.METHODS:
Patients with osteoarthritis and rheumatoid arthritis were enrolled in this study. The relationship between chronic pain intensity and the serum SP concentration was evaluated in these groups of patients with osteoarthritis and rheumatoid arthritis.RESULTS:
The results showed a positive correlation between the serum SP concentrations and chronic pain intensity.CONCLUSIONS:
1. The SP serum concentration was significantly different between the groups of patients with OA and RA. 2. There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substância P
/
Tecido Conjuntivo
/
Dor Crônica
/
Inflamação
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article