Botulinum toxin: an endoscopic approach for treating fecal incontinence.
Endoscopy
; 48(5): 484-8, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26448532
ABSTRACT
BACKGROUND AND STUDY AIMS:
Fecal incontinence is a common, distressing condition with limited therapeutic options. Botulinum toxin A (BTX-A) injections have been proposed as a treatment for patients with fecal incontinence. This study aimed to determine the short-term clinical outcomes of BTX-A injections in patients with fecal incontinence of varying etiology. PATIENTS ANDMETHODS:
Twenty-six patients with fecal incontinence were enrolled, 17 with their native rectum and 9 with a neo-reservoir following a proctectomy for rectal cancer. BTX-A was endoscopically injected into the rectum/reservoir. Scores for severity (CCS) and quality of life (FIQL) were recorded at baseline and at the 3-month follow-up visit.RESULTS:
The CCS was significantly lower after 3 months (median 15, range 4â-â20 vs. 8, range 1â-â19; Pâ=â0.001). The quality of life improved in three of the four FIQL domains. The improvement was maintained in 11 of 12 patients who received more than one injection because of recurrent symptoms. There was no significant predictive factor for the success of BTX-A injections.CONCLUSION:
This preliminary study demonstrated that rectal/reservoir injections are an effective short-term treatment for fecal incontinence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Endoscopia Gastrointestinal
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Toxinas Botulínicas Tipo A
/
Incontinência Fecal
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article