Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood-brain barrier and glioma cells.

Bruun, Jonas; Larsen, Trine B; Jølck, Rasmus I; Eliasen, Rasmus; Holm, René; Gjetting, Torben; Andresen, Thomas L

Bruun, Jonas; Larsen, Trine B; Jølck, Rasmus I; Eliasen, Rasmus; Holm, René; Gjetting, Torben; Andresen, Thomas L.

Afiliação

Bruun J; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark.
Larsen TB; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark.
Jølck RI; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark.
Eliasen R; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark.
Holm R; H Lundbeck A/S, Biologics and Pharmaceutical Science, Valby, Denmark.
Gjetting T; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark.
Andresen TL; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark.

Int J Nanomedicine ; 10: 5995-6008, 2015.

Article em En | MEDLINE | ID: mdl-26451106

Assuntos

Barreira Hematoencefálica; Neoplasias Encefálicas/patologia; Glioma/patologia; Lipídeos/química; RNA Interferente Pequeno/genética; Encéfalo/metabolismo; Neoplasias Encefálicas/tratamento farmacológico; Cátions; Linhagem Celular Tumoral/efeitos dos fármacos; Colesterol/química; Endocitose; Citometria de Fluxo; Inativação Gênica; Glioblastoma/tratamento farmacológico; Glioma/tratamento farmacológico; Humanos; Lipopeptídeos/química; Metaloproteinases da Matriz/metabolismo; Nanopartículas/química; Polietilenoglicóis/química; RNA Interferente Pequeno/metabolismo

Palavras-chave

BBB; angiopep; cleavable PEG-lipid; gene therapy; matrix metalloproteinase; nanocarrier

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Barreira Hematoencefálica / RNA Interferente Pequeno / Glioma / Lipídeos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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