Your browser doesn't support javascript.
loading
Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?
Samuels, Stuart E; Eisbruch, Avraham; Beitler, Jonathan J; Corry, June; Bradford, Carol R; Saba, Nabil F; van den Brekel, Michiel W M; Smee, Robert; Strojan, Primoz; Suárez, Carlos; Mendenhall, William M; Takes, Robert P; Rodrigo, Juan P; Haigentz, Missak; Rapidis, Alexander D; Rinaldo, Alessandra; Ferlito, Alfio.
Afiliação
  • Samuels SE; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Eisbruch A; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
  • Beitler JJ; Departments of Radiation Oncology, Otolaryngology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
  • Corry J; Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
  • Bradford CR; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Saba NF; Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
  • van den Brekel MW; Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  • Smee R; Department of Radiation Oncology, The Prince of Wales Cancer Centre, Sydney, NSW, Australia.
  • Strojan P; Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
  • Suárez C; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Mendenhall WM; Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain.
  • Takes RP; Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
  • Rodrigo JP; Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Haigentz M; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Rapidis AD; Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain.
  • Rinaldo A; Division of Oncology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
  • Ferlito A; Department of Head and Neck Surgery, Greek Anticancer Institute, Saint Savvas Hospital, Athens, Greece.
Eur Arch Otorhinolaryngol ; 273(10): 2877-94, 2016 Oct.
Article em En | MEDLINE | ID: mdl-26463714
ABSTRACT
HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV-) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecções por Papillomavirus Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecções por Papillomavirus Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article