Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.
J Immunol
; 195(10): 4861-72, 2015 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-26466954
ABSTRACT
The importance of Fc-dependent effector functions of Abs induced by vaccination is increasingly recognized. However, vaccination of mice against HIV envelope (Env) induced a skewed Th cell response leading to Env-specific Abs with reduced effector function. To overcome this bias, GagPol-specific Th cells were harnessed to provide intrastructural help for Env-specific B cells after immunization with virus-like particles containing GagPol and Env. This led to a balanced Env-specific humoral immune response with a more inflammatory Fc glycan profile. The increased quality in the Ab response against Env was confirmed by FcγR activation assays. Because the Env-specific Th cell response was also biased in human vaccinees, intrastructural help is an attractive novel approach to increase the efficacy of prophylactic HIV Env-based vaccines and may also be applicable to other particulate vaccines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Anti-HIV
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HIV-1
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Vacinas contra a AIDS
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Linfócitos T Auxiliares-Indutores
/
Produtos do Gene gag do Vírus da Imunodeficiência Humana
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Produtos do Gene pol do Vírus da Imunodeficiência Humana
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Produtos do Gene env do Vírus da Imunodeficiência Humana
Limite:
Animals
/
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article