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Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe.
Bobak, Martin; Malyutina, Sofia; Horvat, Pia; Pajak, Andrzej; Tamosiunas, Abdonas; Kubinova, Ruzena; Simonova, Galina; Topor-Madry, Roman; Peasey, Anne; Pikhart, Hynek; Marmot, Michael G.
Afiliação
  • Bobak M; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BTL, UK. m.bobak@ucl.ac.uk.
  • Malyutina S; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
  • Horvat P; Novosibirsk State Medical University, Novosibirsk, Russia.
  • Pajak A; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BTL, UK.
  • Tamosiunas A; Collegium Medicum, Jagiellonian University, Kraków, Poland.
  • Kubinova R; Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Simonova G; National Institute of Public Health, Prague, Czech Republic.
  • Topor-Madry R; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
  • Peasey A; Collegium Medicum, Jagiellonian University, Kraków, Poland.
  • Pikhart H; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BTL, UK.
  • Marmot MG; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BTL, UK.
Eur J Epidemiol ; 31(1): 21-30, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26467937
Alcohol has been implicated in the high mortality in Central and Eastern Europe but the magnitude of its effect, and whether it is due to regular high intake or episodic binge drinking remain unclear. The aim of this paper was to estimate the contribution of alcohol to mortality in four Central and Eastern European countries. We used data from the Health, Alcohol and Psychosocial factors in Eastern Europe is a prospective multi-centre cohort study in Novosibirsk (Russia), Krakow (Poland), Kaunas (Lithuania) and six Czech towns. Random population samples of 34,304 men and women aged 45-69 years in 2002-2005 were followed up for a median 7 years. Drinking volume, frequency and pattern were estimated from the graduated frequency questionnaire. Deaths were ascertained using mortality registers. In 230,246 person-years of follow-up, 2895 participants died from all causes, 1222 from cardiovascular diseases (CVD), 672 from coronary heart disease (CHD) and 489 from pre-defined alcohol-related causes (ARD). In fully-adjusted models, abstainers had 30-50% increased mortality risk compared to light-to-moderate drinkers. Adjusted hazard ratios (HR) in men drinking on average ≥60 g of ethanol/day (3% of men) were 1.23 (95% CI 0.95-1.59) for all-cause, 1.38 (0.95-2.02) for CVD, 1.64 (1.02-2.64) for CHD and 2.03 (1.28-3.23) for ARD mortality. Corresponding HRs in women drinking on average ≥20 g/day (2% of women) were 1.92 (1.25-2.93), 1.74 (0.76-3.99), 1.39 (0.34-5.76) and 3.00 (1.26-7.10). Binge drinking increased ARD mortality in men only. Mortality was associated with high average alcohol intake but not binge drinking, except for ARD in men.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Doenças Cardiovasculares / Causas de Morte / Intoxicação Alcoólica / Alcoolismo / Consumo Excessivo de Bebidas Alcoólicas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Doenças Cardiovasculares / Causas de Morte / Intoxicação Alcoólica / Alcoolismo / Consumo Excessivo de Bebidas Alcoólicas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article