Peripheral Airway Smooth Muscle, but Not the Trachealis, Is Hypercontractile in an Equine Model of Asthma.

Matusovsky, Oleg S; Kachmar, Linda; Ijpma, Gijs; Bates, Genevieve; Zitouni, Nedjma; Benedetti, Andrea; Lavoie, Jean-Pierre; Lauzon, Anne-Marie

Matusovsky, Oleg S; Kachmar, Linda; Ijpma, Gijs; Bates, Genevieve; Zitouni, Nedjma; Benedetti, Andrea; Lavoie, Jean-Pierre; Lauzon, Anne-Marie.

Afiliação

Matusovsky OS; 1 Meakins-Christie Laboratories, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Kachmar L; 1 Meakins-Christie Laboratories, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Ijpma G; 1 Meakins-Christie Laboratories, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Bates G; 1 Meakins-Christie Laboratories, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Zitouni N; 1 Meakins-Christie Laboratories, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Benedetti A; 2 Department of Medicine, McGill University, Montreal, Quebec, Canada.
Lavoie JP; 3 Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Montreal, Quebec, Canada.
Lauzon AM; 4 Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; and.

Am J Respir Cell Mol Biol ; 54(5): 718-27, 2016 05.

Article em En | MEDLINE | ID: mdl-26473389

Assuntos

Asma/fisiopatologia; Doenças dos Cavalos/fisiopatologia; Contração Muscular/fisiologia; Músculo Liso/fisiopatologia; Traqueia/fisiopatologia; Citoesqueleto de Actina/metabolismo; Animais; Western Blotting; ATPase de Ca(2+) e Mg(2+)/metabolismo; Proteínas Contráteis/metabolismo; Modelos Animais de Doenças; Feminino; Cavalos; Masculino; Cloreto de Metacolina; Miofibrilas/metabolismo; Cadeias Pesadas de Miosina/metabolismo; Miosinas/metabolismo; Mecânica Respiratória/fisiologia

Palavras-chave

airway hyperresponsiveness; airway smooth muscle; asthma; smooth muscle mechanics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Traqueia / Doenças dos Cavalos / Contração Muscular / Músculo Liso Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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