Preparation and in vitro evaluation of Methotrexate-loaded magnetic nanoparticles modified with biocompatible copolymers.
Artif Cells Nanomed Biotechnol
; 44(7): 1733-40, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-26479846
ABSTRACT
Superparamagnetic iron oxide nanoparticles (SPION) are attractive materials that have been widely used in medicine for drug delivery, diagnostic imaging and therapeutic applications. In our study, SPION and the anticancer drug, Methotrexate, were encapsulated into polycaprolactone-polyethylene glycol (PCL-PEG) nanoparticles for local treatment. The magnetic properties conferred by SPION could help to maintain the nanoparticles in the joint with an external magnet. The drug encapsulation efficiency achieved for Fe3O4 magnetic nanoparticles modified with PCL-PEG copolymer was 92.36%. There is potential for use of these nanoparticles for biomedical application.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
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Polietilenoglicóis
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Portadores de Fármacos
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Metotrexato
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Materiais Revestidos Biocompatíveis
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Nanopartículas de Magnetita
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article