Development of chitosan-pullulan composite nanoparticles for nasal delivery of vaccines: optimisation and cellular studies.

Cevher, Erdal; Salomon, Stefan K; Makrakis, Apostolos; Li, Xiong Wei; Brocchini, Steve; Alpar, H Oya

Cevher, Erdal; Salomon, Stefan K; Makrakis, Apostolos; Li, Xiong Wei; Brocchini, Steve; Alpar, H Oya.

Afiliação

Cevher E; a Department of Pharmaceutical Technology, Faculty of Pharmacy , Istanbul University , Istanbul , Turkey .
Salomon SK; b Department of Pharmaceutics , The UCL School of Pharmacy, University of London , London , UK .
Makrakis A; c GlaxoSmithKline , London , UK .
Li XW; b Department of Pharmaceutics , The UCL School of Pharmacy, University of London , London , UK .
Brocchini S; b Department of Pharmaceutics , The UCL School of Pharmacy, University of London , London , UK .
Alpar HO; d PsiOxus Therapeutics Ltd. , Abingdon , Oxfordshire , UK , and.

J Microencapsul ; 32(8): 755-68, 2015.

Article em En | MEDLINE | ID: mdl-26480961

Assuntos

Quitosana; Glucanos; Nanocompostos/química; Vacinas; Administração Intranasal; Animais; Linhagem Celular; Quitosana/química; Quitosana/farmacocinética; Quitosana/farmacologia; Glucanos/química; Glucanos/farmacocinética; Glucanos/farmacologia; Camundongos; Nanocompostos/ultraestrutura; Tamanho da Partícula; Vacinas/química; Vacinas/farmacocinética; Vacinas/farmacologia

Palavras-chave

Carboxymethyl pullulan; N-trimethyl chitosan chloride; cellular uptake; chitosan derivatives; nanoparticles; nasal vaccination; polyion complexation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Quitosana / Nanocompostos / Glucanos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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