Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence.

Ren, Zhi; Cui, Tao; Zeng, Jumei; Chen, Lulu; Zhang, Wenling; Xu, Xin; Cheng, Lei; Li, Mingyun; Li, Jiyao; Zhou, Xuedong; Li, Yuqing

Ren, Zhi; Cui, Tao; Zeng, Jumei; Chen, Lulu; Zhang, Wenling; Xu, Xin; Cheng, Lei; Li, Mingyun; Li, Jiyao; Zhou, Xuedong; Li, Yuqing.

Afiliação

Ren Z; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Cui T; State Key Laboratory of Agricultural Microbiology, Center for Proteomics Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Zeng J; Department of Structural Biology, Key Laboratory of Applied and Environmental Microbiology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China.
Chen L; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Zhang W; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Xu X; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Cheng L; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Li M; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Li J; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Zhou X; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Li Y; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China liyuqing@scu.edu.cn.

Antimicrob Agents Chemother ; 60(1): 126-35, 2016 01.

Article em En | MEDLINE | ID: mdl-26482298

Assuntos

Antibacterianos/farmacologia; Biofilmes/efeitos dos fármacos; Cárie Dentária/tratamento farmacológico; Inibidores Enzimáticos/farmacologia; Glucosiltransferases/antagonistas & inibidores; Quinoxalinas/farmacologia; Fatores de Virulência/antagonistas & inibidores; Animais; Antibacterianos/química; Biofilmes/crescimento & desenvolvimento; Cristalografia por Raios X; Cárie Dentária/microbiologia; Cárie Dentária/patologia; Descoberta de Drogas; Inibidores Enzimáticos/química; Feminino; Expressão Gênica; Glucosiltransferases/química; Glucosiltransferases/genética; Glucosiltransferases/metabolismo; Ensaios de Triagem em Larga Escala; Humanos; Simulação de Acoplamento Molecular; Quinoxalinas/química; Ratos; Ratos Sprague-Dawley; Bibliotecas de Moléculas Pequenas/química; Bibliotecas de Moléculas Pequenas/farmacologia; Streptococcus mutans/efeitos dos fármacos; Streptococcus mutans/enzimologia; Streptococcus mutans/genética; Interface Usuário-Computador; Fatores de Virulência/química; Fatores de Virulência/genética; Fatores de Virulência/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Biofilmes / Cárie Dentária / Fatores de Virulência / Inibidores Enzimáticos / Glucosiltransferases / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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