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Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.
Kim, Se-Ho; Tangallapally, Rajendra; Kim, In Chul; Trovato, Richard; Parker, Daniel; Patton, J Scott; Reeves, Leslie; Bradford, Chad; Wettstein, Daniel; Baichwal, Vijay; Papac, Damon; Bajji, Ashok; Carlson, Robert; Yager, Kraig M.
Afiliação
  • Kim SH; Orthobond Corporation, 675 U.S. 1, North Brunswick, NJ 08902, USA. Electronic address: seho.kimkim@gmail.com.
  • Tangallapally R; St Jude Children's Research Hospital, Department of Chemical Biology, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Kim IC; New Hope Baptist Church, 149 Highland Ave., East Lansing, MI 48823, USA.
  • Trovato R; Jacobs Engineering, 155 N, 400 W., Suite 550, Salt Lake City, UT 84103, USA.
  • Parker D; AvidXchange, 6415 South, 3000 East, Suite 150, Salt Lake City, UT 84121, USA.
  • Patton JS; Arup Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA.
  • Reeves L; Genysis Labs, 391 Orange St, Salt Lake City, UT 84104, USA.
  • Bradford C; Sera Prognostics, 2749 East Parleys Way, Suite 200, Salt Lake City, UT 84109, USA.
  • Wettstein D; MediProPharma, 419 Wakara Way, #207B, Salt Lake City, UT 84108, USA.
  • Baichwal V; Core Diagnostics, 2458 Embarcadero Way, Palo Alto, CA 94303, USA.
  • Papac D; Navigen, 383 Colorow Dr, Salt Lake City, UT 84108, USA.
  • Bajji A; VioGen Biosciences, 1290 West, 2320 South, Suite E, Salt Lake City, UT 84119, USA.
  • Carlson R; Karyopharm Therapeutics, 85 Wells Ave., 2nd Floor, Newton, MA 02459, USA.
  • Yager KM; Myriad Genetic Laboratories, 320 Wakara Way, Salt Lake City, UT 84108, USA. Electronic address: kraig.yager@gmail.com.
Bioorg Med Chem Lett ; 25(22): 5254-7, 2015 Nov 15.
Article em En | MEDLINE | ID: mdl-26483201
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Adenina / Proteínas de Choque Térmico HSP90 / Alanina / Benzodioxóis / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Adenina / Proteínas de Choque Térmico HSP90 / Alanina / Benzodioxóis / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article