Integrin &#945;5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.

Hang, Qinglei; Isaji, Tomoya; Hou, Sicong; Im, Sanghun; Fukuda, Tomohiko; Gu, Jianguo

Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.

Hang, Qinglei; Isaji, Tomoya; Hou, Sicong; Im, Sanghun; Fukuda, Tomohiko; Gu, Jianguo.

Afiliação

Hang Q; From the Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Isaji T; From the Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Hou S; From the Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Im S; From the Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Fukuda T; From the Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Gu J; From the Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan jgu@tohoku-pharm.ac.jp.

J Biol Chem ; 290(49): 29345-60, 2015 Dec 04.

Article em En | MEDLINE | ID: mdl-26483551

Assuntos

Receptores ErbB/metabolismo; Glicosilação; Integrina alfa5/metabolismo; Animais; Biotinilação; Células CHO; Proliferação de Células; Cricetinae; Cricetulus; Feminino; Células HEK293; Células HeLa; Humanos; Microdomínios da Membrana/química; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Mutação; Transplante de Neoplasias; Fosforilação; Estrutura Terciária de Proteína; Transdução de Sinais

Palavras-chave

cell growth; epidermal growth factor receptor (EGFR); glycobiology; glycosylation; integrin; lipid raft; signaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosilação / Integrina alfa5 / Receptores ErbB Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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