Growth and Tolerance of Preterm Infants Fed a New Extensively Hydrolyzed Liquid Human Milk Fortifier.
J Pediatr Gastroenterol Nutr
; 61(6): 665-71, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26488118
ABSTRACT
OBJECTIVES:
This study was a comparison of growth and tolerance in premature infants fed either standard powdered human milk fortifier (HMF) or a newly formulated concentrated liquid that contained extensively hydrolyzed protein.METHODS:
This was an unblinded randomized controlled multicenter noninferiority study on preterm infants receiving human milk (HM) supplemented with 2 randomly assigned HMFs, either concentrated liquid HMF containing extensively hydrolyzed protein (LE-HMF) or a powdered intact protein HMF (PI-HMF) as the control. The study population consisted of preterm infants ≤33 weeks who were enterally fed HM. Infants were studied from the first day of HM fortification until day 29 or hospital discharge, whichever came first.RESULTS:
A total of 147 preterm infants were enrolled. Noninferiority was observed in weight gain reported in the intent-to-treat (ITT) analysis was 18.2 and 17.5 g · kg(-1) · day(-1) for the LE-HMF and PI-HMF groups, respectively. In an a priori defined subgroup of strict protocol followers (nâ=â75), the infants fed LE-HMF achieved greater weight over time than those fed PI-HMF (Pâ=â0.036). The LE-HMF group achieved greater linear growth over time compared to the PI-HMF (Pâ=â0.029). The protein intake from fortified HM was significantly higher in the LE-HMF group compared with the PI-HMF group (3.9 vs 3.3 g · kg(-1) · day(-1), Pâ<â0.0001). Both fortifiers were well tolerated with no significant differences in overall morbidity.CONCLUSIONS:
Both fortifiers showed excellent weight gain (grams per kilograms per day), tolerance, and low incidence of morbidity outcomes with the infants who were strict protocol followers fed LE-HMF having improved growth during the study. These data point to the safety and suitability of this new concentrated liquid HMF (LE-HMF) in preterm infants. Growth with this fortifier closely matches the recent recommendations for a weight gain of >18 g · kg(-1) · day(-1).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Proteínas Alimentares
/
Aumento de Peso
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Alimentos Fortificados
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Nutrição Enteral
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Fórmulas Infantis
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Leite Humano
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article