Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis.

Rubio-Peña, Karinna; Fontrodona, Laura; Aristizábal-Corrales, David; Torres, Silvia; Cornes, Eric; García-Rodríguez, Francisco J; Serrat, Xènia; González-Knowles, David; Foissac, Sylvain; Porta-De-La-Riva, Montserrat; Cerón, Julián

Rubio-Peña, Karinna; Fontrodona, Laura; Aristizábal-Corrales, David; Torres, Silvia; Cornes, Eric; García-Rodríguez, Francisco J; Serrat, Xènia; González-Knowles, David; Foissac, Sylvain; Porta-De-La-Riva, Montserrat; Cerón, Julián.

Afiliação

Rubio-Peña K; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
Fontrodona L; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
Aristizábal-Corrales D; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
Torres S; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
Cornes E; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
García-Rodríguez FJ; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
Serrat X; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
González-Knowles D; Integromics, Integromics SL, Parque Científico de Madrid, 28760, Tres Cantos, Madrid, Spain.
Foissac S; INRA, GenPhySE, F-31326 Castanet-Tolosan, France.
Porta-De-La-Riva M; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain C. elegans Core Facility, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.
Cerón J; Cancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain.

RNA ; 21(12): 2119-31, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26490224

Assuntos

Apoptose; Retinose Pigmentar/genética; Animais; Proteínas Mutadas de Ataxia Telangiectasia/genética; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Caenorhabditis elegans; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/metabolismo; Genes Dominantes; Especificidade de Órgãos; Interferência de RNA; Splicing de RNA; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Retinose Pigmentar/patologia; Ribonucleoproteína Nuclear Pequena U4-U6/genética; Ribonucleoproteína Nuclear Pequena U5/genética

Palavras-chave

C. elegans; RNA-seq; intron retention; retinitis pigmentosa; spliceosome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retinose Pigmentar / Apoptose Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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