Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis.

Miyajima, Rin; Tsuda, Yusuke; Inokuma, Tsubasa; Shigenaga, Akira; Imanishi, Miki; Futaki, Shiroh; Otaka, Akira

Miyajima, Rin; Tsuda, Yusuke; Inokuma, Tsubasa; Shigenaga, Akira; Imanishi, Miki; Futaki, Shiroh; Otaka, Akira.

Afiliação

Miyajima R; Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Tsuda Y; Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Inokuma T; Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Shigenaga A; Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Imanishi M; Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan.
Futaki S; Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan.
Otaka A; Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.

Biopolymers ; 106(4): 531-46, 2016 Nov 04.

Article em En | MEDLINE | ID: mdl-26501985

Assuntos

Peptídeos/química; Análise de Sequência de Proteína; Compostos de Sulfidrila

Palavras-chave

S-cyanylation; hydrazinolysis; native chemical ligation; thioester

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Idioma: En Ano de publicação: 2016 Tipo de documento: Article