Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32.
Mar Drugs
; 13(10): 6489-504, 2015 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-26506361
ABSTRACT
Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5-7, and 9-12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher's and Marfey's methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4-6 and 8-12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicillium
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Bradicardia
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Fármacos Cardiovasculares
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Alcaloides
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article