Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy.

Gao, Rong; Kan, Ming-qiang; Wang, Shi-gang; Yang, Run-hua; Zhang, Shao-gang

Gao, Rong; Kan, Ming-qiang; Wang, Shi-gang; Yang, Run-hua; Zhang, Shao-gang.

Afiliação

Gao R; Department of Emergency and intensive care medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.
Kan MQ; Department of Emergency and intensive care medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.
Wang SG; Department of Emergency and intensive care medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.
Yang RH; Department of Emergency and intensive care medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China. yangrunhua1975@163.com.
Zhang SG; Department of Anesthesiology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.

Inflammation ; 39(2): 550-60, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26508338

Assuntos

Disfunção Cognitiva/patologia; Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo; Cinurenina/metabolismo; Encefalopatia Associada a Sepse/patologia; Sepse/patologia; Triptofano/metabolismo; Animais; Ceco/cirurgia; Modelos Animais de Doenças; Ativação Enzimática; Indolamina-Pirrol 2,3,-Dioxigenase/antagonistas & inibidores; Cinurenina/farmacologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Triptofano/farmacologia

Palavras-chave

cognitive impairment; indoleamine 2, 3-dioxygenase; kynurenine; sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano / Sepse / Indolamina-Pirrol 2,3,-Dioxigenase / Disfunção Cognitiva / Encefalopatia Associada a Sepse / Cinurenina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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