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Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
Ruggeri, Roger B; Buckbinder, Leonard; Bagley, Scott W; Carpino, Philip A; Conn, Edward L; Dowling, Matthew S; Fernando, Dilinie P; Jiao, Wenhua; Kung, Daniel W; Orr, Suvi T M; Qi, Yingmei; Rocke, Benjamin N; Smith, Aaron; Warmus, Joseph S; Zhang, Yan; Bowles, Daniel; Widlicka, Daniel W; Eng, Heather; Ryder, Tim; Sharma, Raman; Wolford, Angela; Okerberg, Carlin; Walters, Karen; Maurer, Tristan S; Zhang, Yanwei; Bonin, Paul D; Spath, Samantha N; Xing, Gang; Hepworth, David; Ahn, Kay; Kalgutkar, Amit S.
Afiliação
  • Ruggeri RB; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Buckbinder L; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Bagley SW; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Carpino PA; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Conn EL; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Dowling MS; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Fernando DP; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Jiao W; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Kung DW; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Orr ST; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Qi Y; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Rocke BN; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Smith A; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Warmus JS; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Zhang Y; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Bowles D; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Widlicka DW; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Eng H; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Ryder T; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Sharma R; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Wolford A; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Okerberg C; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Walters K; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Maurer TS; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Zhang Y; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Bonin PD; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Spath SN; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Xing G; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Hepworth D; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Ahn K; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
  • Kalgutkar AS; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States.
J Med Chem ; 58(21): 8513-28, 2015 Nov 12.
Article em En | MEDLINE | ID: mdl-26509551
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Doenças Cardiovasculares / Peroxidase / Inibidores Enzimáticos / Acetamidas Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Doenças Cardiovasculares / Peroxidase / Inibidores Enzimáticos / Acetamidas Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article